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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | IP | YEAR | Open Career Leaderboard |
|---|---|---|---|---|
| 1 | Steve Carlton | 297.0 | 1976 | |
| 2 | Bert Blyleven | 292.0 | 1978 | |
| 3 | Mike Mussina# | 290.0 | 1991 | |
| 4 | Jon Matlack* | 288.0 | 1983 | |
| 5 | John Montefusco* | 282.0 | 1980 | |
| 6 | John Montefusco* | 281.0 | 1982 | |
| 6 | Catfish Hunter | 281.0 | 1977 | |
| 8 | Mark Fidrych | 280.0 | 1977 | |
| 8 | Mike Mussina# | 280.0 | 1993 | |
| 8 | Kevin Brown# | 280.0 | 1988 | |
| 11 | Catfish Hunter | 279.0 | 1976 | |
| 12 | Bruce Ruffin# | 278.0 | 1990 | |
| 13 | Mike Harkey# | 277.0 | 1992 | |
| 13 | Doc Medich | 277.0 | 1976 | |
| 13 | Dwight Gooden# | 277.0 | 1993 | |
| 13 | Jim Slaton | 277.0 | 1976 | |
| 13 | Jon Matlack* | 277.0 | 1984 | |
| 18 | Mike Mussina# | 276.0 | 1995 | |
| 18 | Jerry Reuss | 276.0 | 1976 | |
| 18 | Mark Fidrych | 276.0 | 1976 | |
| 21 | John Montefusco* | 275.0 | 1981 | |
| 22 | Kevin Brown# | 274.0 | 1993 | |
| 22 | Kevin Brown# | 274.0 | 1989 | |
| 24 | Vida Blue* | 273.0 | 1976 | |
| 25 | John Montefusco* | 272.0 | 1979 | |
| 25 | Wayne Garland | 272.0 | 1976 | |
| 25 | John Montefusco* | 272.0 | 1984 | |
| 25 | Jerry Reuss | 272.0 | 1979 | |
| 25 | Tom Seaver | 272.0 | 1976 | |
| 25 | Mike Mussina# | 272.0 | 1992 | |
| 31 | Mark Guthrie# | 271.0 | 1996 | |
| 31 | Fergie Jenkins | 271.0 | 1976 | |
| 31 | John Montefusco* | 271.0 | 1978 | |
| 31 | Mark Fidrych | 271.0 | 1978 | |
| 35 | Kevin Brown# | 270.0 | 1996 | |
| 35 | Dwight Gooden# | 270.0 | 1989 | |
| 35 | Dennis Eckersley | 270.0 | 1982 | |
| 35 | Steve Rogers | 270.0 | 1976 | |
| 39 | Jim Palmer | 269.0 | 1976 | |
| 39 | Floyd Youmans# | 269.0 | 1987 | |
| 39 | Pedro Martinez# | 269.0 | 1996 | |
| 39 | John Montefusco* | 269.0 | 1976 | |
| 39 | Dwight Gooden# | 269.0 | 1984 | |
| 39 | Steve Carlton | 269.0 | 1977 | |
| 45 | Ken Brett | 268.0 | 1976 | |
| 45 | Catfish Hunter | 268.0 | 1978 | |
| 45 | Randy Johnson# | 268.0 | 1991 | |
| 45 | Gaylord Perry | 268.0 | 1977 | |
| 45 | Bruce Ruffin# | 268.0 | 1989 | |
| 45 | Rick Rhoden | 268.0 | 1982 | |
| 45 | Dwight Gooden# | 268.0 | 1991 | |
| 45 | Dennis Leonard | 268.0 | 1976 | |
| 45 | Ed Halicki | 268.0 | 1979 | |
| 54 | Erik Hanson# | 267.0 | 1992 | |
| 54 | Mike Harkey# | 267.0 | 1989 | |
| 54 | Greg Maddux# | 267.0 | 1990 | |
| 54 | Kevin Brown# | 267.0 | 1990 | |
| 54 | Gary Nolan | 267.0 | 1976 | |
| 54 | Dwight Gooden# | 267.0 | 1990 | |
| 54 | Joe Hesketh | 267.0 | 1987 | |
| 61 | Randy Johnson# | 266.0 | 1993 | |
| 61 | Steve Carlton | 266.0 | 1978 | |
| 61 | Luis Tiant | 266.0 | 1976 | |
| 61 | Greg Maddux# | 266.0 | 1988 | |
| 61 | Kevin Appier# | 266.0 | 1993 | |
| 61 | Dwight Gooden# | 266.0 | 1987 | |
| 61 | Dave Goltz | 266.0 | 1976 | |
| 68 | Jon Matlack* | 265.0 | 1981 | |
| 68 | Dwight Gooden# | 265.0 | 1986 | |
| 68 | Roger Clemens# | 265.0 | 1987 | |
| 68 | Ed Halicki | 265.0 | 1976 | |
| 72 | Randy Tomlin# | 264.0 | 1996 | |
| 72 | Frank Pastore | 264.0 | 1984 | |
| 72 | Greg Maddux# | 264.0 | 1989 | |
| 72 | Marty Pattin | 264.0 | 1979 | |
| 76 | Larry Christenson | 263.0 | 1976 | |
| 76 | Jim Colborn | 263.0 | 1976 | |
| 76 | Andy Rincon | 263.0 | 1982 | |
| 76 | Roger Erickson | 263.0 | 1987 | |
| 76 | Bruce Ruffin# | 263.0 | 1993 | |
| 76 | Greg Maddux# | 263.0 | 1995 | |
| 82 | John Fulgham | 262.0 | 1983 | |
| 82 | Dennis Eckersley | 262.0 | 1977 | |
| 82 | Burt Hooton | 262.0 | 1976 | |
| 82 | LaMarr Hoyt | 262.0 | 1982 | |
| 82 | Dennis Eckersley | 262.0 | 1983 | |
| 82 | Bruce Kison | 262.0 | 1976 | |
| 82 | John Smoltz# | 262.0 | 1996 | |
| 89 | Rudy May | 261.0 | 1976 | |
| 89 | Jim Palmer | 261.0 | 1977 | |
| 89 | Burt Hooton | 261.0 | 1977 | |
| 89 | Tommy John | 261.0 | 1976 | |
| 89 | Wayne Garland | 261.0 | 1978 | |
| 89 | Dennis Leonard | 261.0 | 1977 | |
| 89 | Bruce Kison | 261.0 | 1977 | |
| 89 | Scott Sanderson | 261.0 | 1989 | |
| 89 | Jerry Reuss | 261.0 | 1982 | |
| 98 | Jon Matlack* | 260.0 | 1976 | |
| 98 | Kevin Brown# | 260.0 | 1991 | |
| 98 | Eric Rasmussen | 260.0 | 1976 |
